American Journal of Clinical Case Reports (ISSN: 2766-8347)

The American Journal of Clinical Case Reports (AJCCR) – (ISSN: 2766-5844) is an international, open-access, peer-reviewed journal committed to publishing clinically significant case reports from all medical specialties. Our focus is on real-world cases that offer unique insights into diagnosis, treatment, and patient outcomes.

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The American Journal of Clinical Case Reports (AJCCR) – (ISSN: 2766-5844) is an international, open-access, peer-reviewed journal committed to publishing clinically significant case reports from all medical specialties. Our focus is on real-world cases that offer unique insights into diagnosis, treatment, and patient outcomes. AJCCR welcomes rare presentations, unexpected complications, and novel management approaches that contribute to evidence-based clinical practice. We aim to serve as a global platform for physicians, residents, and healthcare professionals to share and learn from patient-centered experiences. All accepted articles are assigned a DOI and indexed for broad academic visibility.

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Recently Published Articles

Am J Clin Case Rep. 2026;7(1):1120 | Open Access | Case Report

Cancer-Related Microangiopathic Hemolytic Anemia Mimicking Thrombotic Thrombocytopenic Purpura in Metastatic Gastric Signet Ring Cell Carcinoma: A Fatal Diagnostic Pitfall

Lina Alkhdour*, Osama El Khatib, Nazmi Kamal and Kamal Al-Rabie
 

Cancer-related microangiopathic hemolytic anemia is a rare but severe paraneoplastic syndrome most commonly associated with advanced solid tumors, particularly gastric signet ring cell carcinoma. Its ...

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Am J Clin Case Rep. 2026;7(1):1118 | Open Access | Case Report

Surgical Case Report: Renal Angiomyolipoma with Inferior Vena Cava Involvement

Giuliana Martello, Lisa Licini, Carlo Beretta, Luigi Filippo Da Pozzo and Marco Roscigno

Renal angiomyolipoma (AML) is a benign mesenchymal renal tumor composed of abnormal blood vessels, smooth muscle, and adipose tissue. Although most AMLs are incidentally detected ...

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Am J Clin Case Rep. 2026;7(1):1117 | Open Access | Case Report

In Digestive Endoscopy Not Everything Is Always at First Sight

Greco S*, Burti C, Grieco L, Occhipinti V and Marra P

We illustrate a case of gastric bleeding secondary to a lesion that is not easily visible and where endoscopic ultrasound reveals the vascular anomaly. ...

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Am J Clin Case Rep. 2026;7(1):1115 | Open Access | Case Report

Post-Esophagectomy Chylothorax: The Impact of Thoracic Duct Embolization on Clinical Outcomes

Juliana Ribeiro*, Margarida Rouxinol, Silvia Silva, Ana Melo, Pedro Costa, Herculano Moreira and João Pinto-de-Sousa

Chylothorax, an accumulation of chyle in the pleural cavity, typically occurs due to thoracic duct damage, presenting as a milky exudate with high lymphocyte and ...

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Am J Clin Case Rep. 2026;7(1):1114 | Open Access | Case Report

Rectal Prolapse: Is All-In a Good Option? A Case Report

Ribeiro J*, Dupont M, Marques C, Marques R, Moreira H and Pinto-de-Sousa J

Rectal prolapse is defined as the protrusion of full thickness rectal wall through the anal canal. It is a debilitating pelvic floor disorder and significantly ...

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Am J Clin Case Rep. 2025;6(1):1110 | Open Access | Case Report

Successful Treatment of Refractory Oral Lichen Planus Using Upadacitinib

Binkowski A, Sachdeva S*, Goodman M and Louis D

Oral lichen planus is a chronic, immune-mediated disorder marked by T-cell-driven inflammation targeting basal keratinocytes. Conventional treatments, including topical corticosteroids and calcineurin inhibitors, often provide ...

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Am J Clin Case Rep. 2026;7(1):1113 | Open Access | Image Article

Pneumatosis Intestinalis in Necrotizing Enterocolitis

Han X, Yang L and Zhang L

A 14-day-old full-term girl was transferred to our hospital with hematochezia, fever, and poor feeding. Physical examination revealed abdominal tenderness and hypoactive bowel sounds. Abdominal ...

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Am J Clin Case Rep. 2025;6(1):1112 | Open Access | Case Report

A Metachronous Virchow’s Node Metastasis from Right-Sided Colon Adenocarcinoma Following Curative Resection: A Case Report

Bruno Vieira*, Artur Ribeiro and João Pinto-de-Sousa

Background: Colorectal Cancer (CRC) commonly metastasizes to the liver and lungs. Metastasis to Virchow’s Node (VN), the left supraclavicular lymph node, is rare ...

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Am J Clin Case Rep. 2025;6(1):1111 | Open Access | Case Report

HMG-CoA Reductase Autoantibody-Mediated Myositis: A Case Report

Lobmann R*, Barmpa I, Chatzitomaris A and Bäzner H

Statin-associated muscle symptoms are a common adverse effect of statin therapy; however, not all cases of muscle pain necessarily require discontinuation of treatment. We report ...

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Am J Clin Case Rep. 2025;6(1):1109 | Open Access | Case Report

Bridging Two Worlds: The First Hybrid Dual-Graft Liver Transplantation Combining Whole Deceased and Living Donor Grafts

Al-Hamoudi W, Zidan A and Broering D

The persistent mismatch between organ availability and demand continues to drive innovation in liver transplantation. Dual-graft transplantation represents a novel solution to overcome graft-size limitations ...

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Am J Clin Case Rep. 2025;6(1):1108 | Open Access | Case Report

Secondary Omental Torsion Following Central Pancreatectomy Managed Conservatively: A Case Report

khadija Alenawi, Mahnd Alaenezi, Noor Shammouh, Shaimaa Dashti, Afaq Alkhalil and Salah Termos*

Omental torsion is a rare condition caused by twisting of the greater omentum, leading to compromised blood flow and ischemia. Because its symptoms mimic other ...

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Am J Clin Case Rep. 2025;6(1):1101 | Open Access | Case Report

Pancytopenia Induced by Endocrine Dysfunction Following Craniopharyngioma Resection

Stein M, Ibrahim A, Kadamov Y and Chelliah T

Pancytopenia is a rare but reversible complication of endocrine dysfunction. We present a case of a 59-year-old female with adrenal insufficiency and hypothyroidism secondary to ...

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Am J Clin Case Rep. 2025;6(1):1105 | Open Access | Case Report

Displaced Proximal Humerus Fracture in an Adolescent Following a Rugby Injury

Shaza Ali, Humayun Hijazi and Eoin Sheehan

A teenage boy was referred with a proximal humerus fracture after he injured his shoulder while participating in a rugby match. The initial imaging studies ...

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Am J Clin Case Rep. 2025;6(1):1102 | Open Access | Case Report

Uterine Malformations Discovered Incidentally During Emergency Caesarean Sections in Full-Term Pregnancies in the Northeastern Part of the Democratic Republic of Congo: About 3 Cases and Review of the Literature

Alain BM, Faustin MV, Daniel EM, Wasingya DK, Claude KM and Sévérin UA

Introduction: Uterine malformations, or Mullerian anomalies, are secondary to the absence of migration or incomplete caudal migration, or a defect in the fusion of the ...

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Am J Clin Case Rep. 2025;6(1):1103 | Open Access | Case Report

A Successful Application of NGS-guided Precision Medicine in Ewing Sarcoma in Iran: A Case Report

Shahdad Farokhmanesh, Omid Reza Zekavat, Mohammadreza Bordbar, Golsa Shekarkhar, Mahdi Shahriari, Hadi  Mottaghipisheh  and Ramin Ajami

Background: Ewing sarcoma is a rare, aggressive malignancy of bone and soft tissue, primarily affecting adolescents and young adults. Even with access to standard ...

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Am J Clin Case Rep. 2025;6(1):1100 | Open Access | Case Report

Acute Limb Ischaemia Following Delayed Coil Migration After Embolization of A Common Femoral Artery Aneurysm: A Case Report

Eng C and Hamish M

Background: Endovascular coil embolization is a minimally invasive technique widely used for managing aneurysms. While effective, complications such as coil
migration are rare but ...

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Am J Clin Case Rep. 2025;6(1):1099 | Open Access | Case Report

Melorheostosis of the Knee: A Rare Cause of Chronic Pain and Functional Impairment in a Young Adult Male

Ali SNO, Hijazi H and Sheehan E

This case report discusses few aspects of melorheostosis in a male patient in early thirties with several years of progressive knee  pain and stiffness, ...

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Am J Clin Case Rep. 2025;6(1):1098 | Open Access | Case Report

A Case Report: Systemic-Onset Juvenile Idiopathic Arthritis Complicated by Peripheral Gangrene in A 9-Year-Old Girl

Karabuga V, Gurler B, Diarra MF, Yazgan H and Diallo A

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disorder that can lead to a range of complications in children. Vasculitis is a rare but severe ...

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Am J Clin Case Rep. 2025;6(1):1097 | Open Access | Case Report

Breast Cancer Tumoral Heterogeneity: A Case Report of the Discovery of Multiple Heterogeneous Foci of Invasive Carcinoma Arising Within the Right Breast

Lien C, Gilbert J, Velazquez C and Margheim B

We report the case of a 50-year-old female with bilateral breast implants who presented with indeterminate, pleomorphic, linear, branching ductal calcifications in the right breast. ...

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Am J Clin Case Rep. 2025;6(1):1096 | Open Access | Research Article

Diaphragmatic Clear Cell, Carcinoma Associated with Endometriosis: Second Case Report and Literature Review

Gómez de la Rosa AG, Quesada López-Fe AA, Vilar Chesa M, Pérez Álvarez JA, Concepción Martín V, Garrido Carrasco M4, Pantoja Ortiz V, Preckler Peña DJ, Sánchez-Pinto Hernández C, Moreno Duque D, Suárez Díaz M and Boria Alegre F

Endometriosis is a chronic, inflammatory gynecological condition that can undergo malignant transformation and was first described in 1925. While endometriotic implants are most commonly located in ...

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Am J Clin Case Rep. 2024;5(3):1095 | Open Access | Case Report

A Rare Case of Parotid Gland Lipoma

Ibtissam L , Naanani O, Loudghiri M, Bijou W, Rouadi S, Abada RL, Roubal M and Mahtar Mb

It is quite uncommon for lipomas to occur in the parotid region. We present a novel case and evaluate the literature for a 59-year-old deaf-dumb ...

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Am J Clin Case Rep. 2024;5(2):1094 | Open Access | Case Report

Benign Oral Lesions, Rare in Newborns: Fordyce Granules

María Elena Venegas Lorena Velandiaand Daniela Moreno

Background: In neonatology and pediatrics, doctors conduct the initial assessment of a newborn’s oral health, which is crucial in differentiating between ...

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Am J Clin Case Rep. 2024;5(2):1093 | Open Access | Case Report

Abducent Nerve Palsy in Herpes Encephalitis: A Case Report

Rashmi Rajur and Shivanand Pai

We describe a case of 50-year-old male who developed a sixth nerve palsy after the diagnosis of herpes encephalitis. Neuroimaging showed medial temporal lobe hyperintensities. ...

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Am J Clin Case Rep. 2024;5(2):1092 | Open Access | Research Article

Role of Tirzepatide in the Management of Type 2 Diabetes and Obesity

Suha Albahrani

Tirzepatide is a GIP-analogue that activates both the GLP-1 and GIP receptors, leading to improved blood sugar control in addition to favorable weight loss effect. ...

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Am J Clin Case Rep. 2024;5(2):1091 | Open Access | Opinion

The COVID-19 Vaccine

Mihnea Orza

1.COVID-19 was created in a laboratory, through repeated sequencing – therefore, it was not created by nature, but artificially based on mutated viruses. <...

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Am J Clin Case Rep. 2024;5(2):1090 | Open Access | Case Report

Delayed Neutropenia Following Single Agent Adjuvant Nivolumab for Melanoma

Haadi A Ali , Nathaniel R, Wilson and Leslie A Fecher

Nivolumab in combination with ipilimumab is standard of care for metastatic melanoma. While immunotherapy provides a survival benefit, it is associated with immune related adverse ...

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Am J Clin Case Rep. 2024;5(1):1089 | Open Access | Case Report

Disseminated CMV Infection Associated Hemophagocytic Lymphocytosis in an Iatrogenic Immunocompromised Host

Haadi Ali , Jawad Bouhamdan, Madison Butler, Nathaniel R Wilson, Nathaniel Christian-Miller and Asra Ahmed

Hemophagocytic Lymphohistiocytosis (HLH) is a rare hematological condition that presents as a sequela of an underlying pathological process CMV has been documented to be a ...

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Am J Clin Case Rep. 2024;5(1):1088 | Open Access | Case Report

Camphor: A Common Substance, An Uncommon Cause of Seizure

Varoon Vadodaria and Shivananda Pai

Camphor, a readily available substance, presents itself as a colourless or white crystalline powder or cubes, characterized by a potent mothball-like fragrance. Possessing a density ...

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Am J Clin Case Rep. 2024;5(1):1087 | Open Access | Case Report

Toxoplasmosis of the Central Nervous System in the Late Period after Transplantation

Barbara Piekarska , Anna Zawiasa-Bryszewska, Anetta Barczak, Magdalena Pawlak , Anna Piekarska and Ilona Kurnatowska

Background: Cerebral toxoplasmosis is extremely rare in Kidney transplant (KTx) recipients. In most reported cases, infection is activated in the early postoperative ...

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Am J Clin Case Rep. 2024;5(1):1086 | Open Access | Research Article

Clinical Characteristics, Treatment and Outcome of Gunshot Injuries in South West Region of Cameroon

Ngomba Divine Martin Mokake,, Nkemnguatem Nelson Atabong , Ekani Boukar , Ekwa Monono Yawa , Nana Theophile , Ngwane Ntongwetapem , Esembeson Malika , Nalova Mwambo , Chichom Meferi Alain and Ngowe Ngowe Marcelin

Background: Gunshot injuries have been on the rise in the south west region of Cameroon for the past 6 years due to the current ...

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